Have you heard of the term exosome, which has become a hot topic in recent years? Exosomes are capsule-like substances covered by a membrane that are produced by every cells in the body. When cells are magnified under an electron microscope, exosomes can be seen as round balls with protrusions around them. There are growing expectations for the application of exosomes in testing and as a new therapeutic tool for a variety of diseases. In the field of testing, exosomes are used for the early detection of cancer. Recently, exosomes have also been applied to cosmetic medicine, attracting attention to their anti-aging and skin beautifying effects.In this article, we will discuss the anti-aging and skin beautifying effects of exosomes in detail.
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Exosomes, as mentioned earlier, are extracellular membrane-bound substances. In recent years, various studies have shown that exosomes, which are responsible for information exchange and transmission between cells, are released not only from human cells but also from various plant and animal cells in nature and have a significant impact on the lives of all living organisms. There are many different types of capsule-like substances covered by extracellular membranes, especially those around 100 nm in size, which are called exosomes. Exosomes contain nucleic acids (microRNA, messenger RNA, DNA, etc., commonly called genes) and proteins that carry information necessary for the creation of new cells.
In recent years, many of the exosomes that have become a hot topic in the field of regenerative medicine are mesenchymal stem cells (cells capable of differentiating into various cell types such as skin, bone, fat, cartilage, and muscle) derived. , which are also used in our clinic. Mesenchymal cells are attracting attention in the field of regenerative medicine and are said to promote repair and functional regeneration of damaged tissues.
Exosomes have been shown to contain anti-inflammatory cytokines (proteins that reduce inflammation in the body and aid in tissue repair) that not only repair tissue function by promoting cell proliferation and wound healing, but also have therapeutic effects on various areas of disease, such as myocardial infarction and neurological disease. It is also known to alleviate liver dysfunction and is increasingly expected to treat liver diseases.
Our exosome therapy and exosome IV infusions used in our clinic are derived from mesenchymal stem cells (cells capable of differentiating into various cell types such as skin, bone, fat, cartilage, and muscle). Mesenchymal-derived stem cells secrete a large number of exosomes that take advantage of the strong paracrine effect (acting directly on neighboring cells and tissues to promote repair and growth). Exosomes are released from cells and do not contain cellular components, so they are not subject to the Law for Ensuring the Safety of Regenerative Medicine (It is prohibited in Japan to put other people's cells into your body). Therefore, there is no substantive legal regulation, and there is a concern that the treatment may be performed without sufficient evidence of safety and efficacy. The exosomes used in Ginza Beauty Medical Clinic are generated at the reliable "Japan Biotherapy Institute", where the raw materials and manufacturing process are well controlled, and are of high quality and reliability.
Exosomes communicate and exchange information between cells, and it is known that cells can regulate each other's functions through exosomes. This is applied to skin regeneration and anti-aging.
In addition to anti-aging care such as the improvement of wrinkles, it is also expected to support the recovery of physical aging(sluggishness, shallow sleep, motivation, joint pain, menopausal symptoms and etc.).
Exosome IV infusion or injecting exosomes into the scalp help activate hair follicles and increase hair volume/improve thinning hair in both men and women.
The Japan Biotherapy Institute's StemSup® exosomes used in Ginza Beauty Medical Clinic include adipose-derived exosomes, dental pulp-derived exosomes, and umbilical cord-derived exosomes. Each contains different active substances, and we will discuss which exosome to use depending on the patient's concerns in the examine.
The potent growth factor (HGF) that promotes tissue growth and regeneration contained in the stem cell culture supernatant we use has been found to be 2 to 5 times higher than other companies' products, and exosomes that promote tissue repair by inducing cellular responses such as cell proliferation and functional expression are approximately 100 times higher.
Fat from healthy Japanese women are used.
Dental pulp from Japanese children are used.
Growth factors from dental-pulp derived stem cellsinclude more potent growth factors.
Umbilical cord from Japanese babies are used
Compared to fat and dental pulp, umbilical cord exosomes are said to have superior ability of tissue repair, immune regulation, tissue healing, and anti-inflammatory effects.
The method of exosomes injection differs depending on the purpose of therapy.
For skin regeneration of the face, body, back, etc., direct injection with Bellapro injectors is recommended.
Exosome infusion is recommended for anti-aging, skin problems such as atopic dermatitis, fatigue, and prevention of other diseases. An infusion takes 15-30 minutes.
Nasal absorption of exosomes into the body through intranasal drip is effective for physical anti-aging as well as intravenous drip, especially in preventing the progression of Alzheimer's disease and improving cognitive functions. It works on the brain via the olfactory nerve.
Exosome eye drops (eye drops) are effective for tired eyes and dry eyes.
We prescribe exsosome eye drops.
After 1 time injection of exososme,
VISIA's score improved from 88 to 97.
After 4 months
After 1 time injection of exosome,
VISIA's score improved from 76 to 95.
After 7 months
The pores are smaller.
VISIA's score improved from 64 to 94.
After 1 time injection of exosome,
VISIA's score improved from 48 to 94.
VISIA's score improved from 16 to 84.
Please come to clinic as scheduled.
We would like you to cleanse your face so that the doctor can diagnose your skin condition. If you wish to do an exosome infusion, you don't need cleansing.
We have the VISIA skin analysis in our clinic.
VISIA is an in-depth analysis of your individual facial characteristics.
It lets you see the benefits of skin care programs planned for your specific complexion.
The doctor will examine you.
Anesthetic cream is applied in advance for local exosome injections.
※If you wish facial pack, you can add from our pack choices.
The infusin takes about 15 to 30 minutes.
After topical injection of Exosome, do not wash your face or use lotion or emulsion for about 6 hours after the procedure in order to promote the penetration of Exosome. We recommend that makeup be applied the following day. There are no restrictions for those who receive exosome infusion.
We will follow you up whenever you need.
03-6264-6330
